I am a physician-scientist with a focus on exploring the mechanisms of allograft rejection and autoimmunity with ultimate goal of establishing novel immunoregulatory strategies to promote graft acceptance and to treat autoimmune diabetes. Over the past several years, we have built a multidisciplinary team encompassing experts in tissue engineering, department of material sciences, and bioinformatics to address some of the challenges in transplantation and other complex diseases such as type 1 diabetes.

Publications

El Haddad N, Heathcote D, Moore R, Yang S, Azzi J, Mfarrej B, Atkinson M, Sayegh MH, Shin Lee, Ashton-Rickardt PG, Abdi R. Mesenchymal Stem Cells express Serine Protease Inhibitor to evade host immune response. Blood. 2011 Jan 27;117(4):1176-83.

Azzi J, Moore RF, Elyaman W, Mounayar M, El Haddad N, Takakura A, Petrelli A, Fiorina F, Ruckle T and Abdi R. The novel therapeutic effect of PI3Kγ inhibitor, AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61(6):1509-18.

Zandi-Nejad K, Takakura A, Jurewicz M, Chandraker AK, Offermanns S, Mount D, Abdi R. The role of HCA2 (GPR109A) in regulating macrophage function. FASEB J. 2013 Jul 23.

Azzi J, Skartsis N, Mounayar M, Magee CN, Batal I, Ting C, Moore R, Riella LV, Ohori S, Abdoli R, Smith B, Fiorina P, Heathcote D, Bakhos T, Ashton-Rickardt PG, Abdi R. Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells. J Immunol. 2013 Sep 1;191(5):2319-27.

Ibrahim Batal, Jamil Azzi, Marwan Mounayar, Robert Moore, Jack Y Lee, Florencia Rosetti, Chang Wang, Paolo Fiorina, Robert Sackstein,Takaharu Ichimura, Reza Abdi. The mechanisms of up-regulation of dendritic cell activity by oxidative stress. Journal of Leukocyte Biology. In Press

Appointments

Associate Professor of Medicine
Harvard Medical School
Transplant Nephrologist
Brigham and Women’s Hospital

 

Education

1991 – MD, Beheshti University of Medical Sciences, Tehran, Iran

 

Awards & Honors

2007 – National kidney foundation clinical scientist award, National Kidney Foundation

2011 – AST Basic Scientist Award, American Society of Transplantation

2012 – Advancing Research in Transplantation Science (ARTS) Awards, Pfizer

2014 – American Diabetes Association Basic Science Award

 

Contact

Phone: 617-732-7249
Fax: 617-732-5254
E-Mail: rabdi@partners.org