Despite tremendous advances towards the improvement in 1-year graft survival, long-term allograft failure and side effects of immunosuppressive agents remain key obstacles.  Novel strategies are needed to promote transplantation tolerance and prevent chronic rejection.

A well-coordinated interplay between antigen presenting cells (APCs) and T cells is central to rejection: following delivery to the draining lymph node, foreign antigen is presented by APCs, leading to activation of T cells that exert their effector activity upon return to the graft tissue. Keys to understanding this process include an understanding of the temporal and spatial interplay of these cellular interactions, as well as knowledge about how T cell activation is controlled by costimulatory pathways.

My current research activities focus on the following areas:

  • How T cell costimulatory pathways, particularly the TIM (T cell immunoglobulin mucin domain) family of costimulatory molecules, affect immune cell activation versus regulation
  • The role of Th17 cells and plasticity of regulatory T cells in mediating transplant rejection
  • Use of novel imaging techniques including intravital microscopy to better understand immune cell migration and the cellular interactions which dictate graft rejection versus tolerance (in collaboration with Takuya Ueno, Instructor of Radiology, Massachusetts General Hospital)

 

Publications

Yeung MY, McGrath M, Najafian N. The Emerging Role of the TIM Molecules in Transplantation. Am J Transplant. 2011 Oct; 11(10):2012-9.

M.Y. Yeung, M. McGrath, M. Nakayama, T. Shimizu, O. Boenisch, C.N. Magee, R. Abdoli, H. Akiba, T. Ueno, L.A. Turka, N. Najafian. Interruption of Dendritic Cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immun. 2013 Oct 15;191(8):4447-4455. Epub 2013 Sep 13.  PMID: 24038092

Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, Rothstein DM. Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest. 2011 Sep 1; 121(9):3645-56.

B. Schröppel, B. Krüger, L. Walsh, M. Yeung, S. Harris, K. Garrison, J.  Himmelfarb, S.M. Lerner, J.S. Bromberg, P.L. Zhang, J.V. Bonventre, Z. Wang, A.B. Farris, R.B. Colvin, B.T. Murphy, J.P. Vella.  Tubular expression of KIM-1 does not predict delayed graft function after transplantation.  JASN. 2010 Mar;21(3):536-42.

M.Y. Yeung*, T. Ueno*, M. McGrath, S. Yang, N. Zaman, B. Snawder, R. Padera, C.N. Magee, R. Gorbatov, M. Hashigucki, M. Azuma, G.J. Freedman, M. Sayegh, and N. Najafian. Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur J Immunol. 2012 Sep;42(9):2343-53. doi: 10.1002/eji.201242501. PMID: 22733595. *Co-first authors

Appointments

Instructor in Medicine, Harvard Medical School

Associate Physician, Brigham & Women’s Hospital

 

Education

2000 – BSc, University of Toronto, Toronto, Ontario, Canada

2003 – MD, University of Ottawa, Ottawa, Ontario, Canada

2007 – Maine Medical Center, Portland, ME, Internal Medicine Residency, 2007

2008 – Massachusetts General Hospital/Brigham & Women’s Hospital, Boston, MA, Nephrology Fellowship

2009-2011 – Brigham & Women’s Hospital, Boston, MA, Postdoctoral fellow

 

Awards & Honors

2008-2010 – Postdoctoral Research Fellowship Grant –National Kidney Foundation

2010 – Basic Science Award, Genzyme Annual Fellows Conference

2010 – Young Investigator Award, American Transplant Congress

2010-2013 – Inaugural Chair – Trainee and Young Faculty Community of Practice, American Society of Transplantation

2010-2011 – Basic Science Advisory Council, American Society of Transplantation

2011-2012 – Grants Committee, American Society of Transplantation

2011-2016 – Fellow-to-Faculty Transition Award –American Heart Association

2013 – Outstanding Abstract Award, American Association of Immunologists

 

Contact

Phone: 617-525-8005
Fax: 617-732-5254
Email: myeung@partners.org