At the TRC, our research is at the forefront of current knowledge in immunology and transplantation. We strive to build upon this using a wide range of immune studies and techniques, to look at various aspects of transplant immunology and rejection.
All of our work is focused on the ultimate aim of improving the outcomes for patients who receive a solid organ transplant.
Our research focus includes:
Studying the immune response to a transplanted organ using animal models. We aim to more fully understand what leads to acute and chronic rejection and what are the steps along the way that could be affected to prevent rejection from occurring. These studies are crucial to pursue newer, more effective drugs in transplantation.
Identifying and targeting new pathways to improve transplant survival. By these studies, we will uncover new targets and work on the development of new drugs that may be beneficial to transplant recipients. These exciting studies use new drugs alone or in combination with current anti-rejection drugs to block transplant rejection from a number of different angles.
The development of new approaches to prevent transplant rejection. Using new technologies for drug delivery, including nanotechnology and techniques to deliver drug to the site where they are required, we work towards achieving greater success with currently used anti-rejection drugs, and at the same time decrease the side effects and complications associated with them.
Identification of biomarkers of transplant rejection and injury. Currently, transplant rejection is diagnosed by biopsy, which carries risks to the patient and the transplanted organ. Biomarkers are tests, based on either blood or urine that could diagnose rejection without the need for biopsy. Other biomarkers could tell us which patients require more or less immunosuppressive medication and help us to more individually tailor treatment to each patients need.
Development of new tools to visualize the immune response. Using cutting-edge technology and new imaging techniques, we are working on ways to be able to directly monitor the immune response by imaging. The ability to study how immune cells interact with each other in a live organism will provides incredible insight into the mechanism of transplant injury and failure, and will help us develop better and more targeted therapies for transplant patients.