Dr. McGrath is an Instructor in Medicine at Harvard Medical School and Associate Physician at Brigham and Women’s Hospital, where she attends on the Transplant and General Nephrology services.  As an active and successful physician-scientist, she devotes time to both patient care and laboratory-based research. Her clinical interest lies in transplantation and other forms of immune-mediated kidney disease, including glomerulonephritis. Her research is focused on improving our understanding of the mechanisms involved in transplant rejection, and developing innovative therapeutic approaches that will improve outcomes for transplant patients.Her current projects include:

  • Examining the role of the costimulatory molecule, TIM-4, in transplant rejection. By targeting this pathway, she aims to promote the development of regulatory T cells, leading to improved function and survival of solid organ transplants.

 

  • Assessing the role of IL-17 producing T cells (Th17 cells) in transplant rejection and analyzing the effect of clinically used immunosuppressive agents on the function of these cells.

 

 

 

Selected Publications

Interruption of Dendritic Cell-Mediated TIM-4 Signaling Induces Regulatory T Cells and Promotes Skin Allograft Survival. Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N. J Immunol. 2013 Oct 15;191(8):4447-55.

Fetal outcomes after rituximab exposure in women with autoimmune vasculitis. Pendergraft WF 3rd, McGrath MM, Murphy AP, Murphy P, Laliberte KA, Greene MF, Niles JL. Ann Rheum Dis 2013 Dec;72(12):2051-3.

Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Takuya Ueno*, Melissa Y. Yeung*, Martina McGrath, Sunmi Yang, Nadia Zaman, Benjamin Snawder, Robert F. Padera, Ciara N. Magee, Rostic Gorbatov, Masaaki Hashiguchi, Miyuki Azuma, Gordon J. Freeman, Mohamed H. Sayegh, and Nader Najafian. European Journal of Immunology 2012 Sep;42(9):2343-53.

The Role of Co-inhibitory Signaling Pathways in Transplantation and Tolerance. McGrath Martina M., Najafian Nader. Frontiers in Immunology 2012,3:47

The Emerging Role of the TIM Molecules in Transplantation. Yeung MY, McGrath M, Najafian N. Am J Transplant. 2011 Oct;11(10):2012-9. Epub 2011 Sep 11.

Contaminated Cocaine and Antineutrophil Cytoplasmic Antibody-Associated Disease. McGrath MM, Isakova T, Rennke HG, Mottola AM, Laliberte KA, Niles JL. Clin J Am Soc Nephrol. 2011 Dec;6(12):2799-805

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Appointments

Instructor in Medicine, Harvard Medical School 

Associate Physician, Brigham and Women’s Hospital

 

Education

University College Cork, Ireland, MB, BCh, 2001

Internal Medicine Residency, Beaumont Hospital, Dublin, Ireland, 2002-2004

Nephrology Higher Specialist Training Program, Ireland, 2004-2009

Nephrology Fellowship, Brigham and Women’s/Massachusetts General Hospital, 2009-2012

 

 

Awards & Honors

Basic Science Fellowship Award, American Society of Transplantation, 2011-2013

Young Investigator Award, American Transplant Congress, 2011

Young Investigator Award, National Kidney Foundation, 2013-2014

Paul Teschan Research & Development Award, DCI, 2013-

Fellow of the American Society of Nephrology, American Society of Transplantation, 2013-

National Fellow to Faculty Transition Award, American Heart Association 2014-2019

 

 

Contact

mmcgrath8@partners.org
Phone: 617 732-5897
Fax: 617 732-5254